Deterioration of blood lipids during early postoperative remission of Cushing's syndrome: a longitudinal cohort study
Authors' conclusion
During the early remission phase following curative surgery for CS, we observed a further deterioration in lipid parameters.
Study context
- Population
- Patients with endogenous cushing's syndrome (CS) undergoing curative surgery, LMU Hospital, Munichn = 23 at 24 months
- Participants
- 26 patients
- Exposure
- Postoperative remission vs active CS; CS vs matched controls at baseline
- Active CSn = 26reference
- Controlsn = 26
- Outcome
- Lipid profiles (total cholesterol, LDL, HDL, ApoA1, ApoB, lipoprotein (a), TG, non-esterified fatty acids) and metabolic markers
- Follow-up
- Before surgery and 1, 3, 6, 12 and 24 months after surgery
Methodological detailssingle-centre, age-, BMI- and sex-matched controls
- Single-centre
- Age-, BMI- and sex-matched controls
Main finding
As reported in the abstract
HDL · 1 month postoperative
P < 0.0001
Observational data: associations, not effects.
Further findings
mg/dL
| Outcome | Active CS | Postoperative | P value |
|---|---|---|---|
| ApoA1 · 1 month postoperativePostoperative vs Active CS · lower postoperatively | 193 (range 169–211) | 160 (range 147–168) | P < 0.0001 |
| TG · 1 month postoperativePostoperative vs Active CS · higher postoperatively | 129 (range 89.3–186) | 185 (range 154–218) | P < 0.0001 |
TG-glucose index and non-esterified fatty acids
- TG-glucose index increased during early remission, positively correlated with CRP and IL-6
- Non-esterified fatty acids showed 3 distinct postoperative trajectories depending on baseline BMI
Original publication
Deterioration of blood lipids during early postoperative remission of Cushing's syndrome: a longitudinal cohort study. J Clin Endocrinol Metab. Published 24 April 2026. doi:10.
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