Low-grade inflammation during the glucocorticoid withdrawal phase in patients with Cushing's syndrome
Authors' conclusion
The glucocorticoid withdrawal phase is associated with a low-grade inflammatory state, which is particularly pronounced in obese and hyperglycemic patients and related to lower muscle function.
Study context
- Population
- Patients with endogenous Cushing's syndrome (CS) who underwent successful surgery, German Cushing's registry, 2012–2021case-control in 25
- Participants
- 80 patients
- Comparison
- 1 month after surgery vs active CS
- Outcome
- Inflammatory markers C-reactive protein and interleukin-6
Methodological detailslongitudinal, registry-based, age-, gender- and BMI-matched controls
- Longitudinal
- Registry-based
- Age-, gender- and BMI-matched controls
Main finding
As reported in the abstract
C-reactive protein · 1 month after surgery
P ≤ 0.001
Observational data: associations, not effects.
Further findings
Median, pg mL-1
| Outcome | Postoperative remission | Active CS | P value |
|---|---|---|---|
| Interleukin-6 · 1 month after surgeryPostoperative remission vs Active CS | 7.2 (IQR 3.3–11.7) | 1.7 (IQR 1.5–2.5) | P ≤ 0.001 |
Determinants, duration and correlates of inflammation
- Obesity and hemoglobin A1c (HbA1c) associated with increased inflammation levels
- Proinflammatory state lasted until 1 year after surgery
- Inflammatory markers in early remission inversely correlated with long-term muscle function
Original publication
Low-grade inflammation during the glucocorticoid withdrawal phase in patients with Cushing's syndrome. Eur J Endocrinol. Published 27 March 2023. doi:10.
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