Altered Microbiome Signature in Cushing's Syndrome Persists Beyond Remission
Authors' conclusion
Patients with CS have a distinct and disturbed gut microbiome that persists even after surgery, indicating a possible target for additional probiotic interventions to accelerate convergence to a healthy microbiome.
Study context
- Population
- Patients with endogenous Cushing's syndrome (CS) (mainly pituitary CS, n = 13), sampled during active CS and 1 to 2 years after successful surgery in biochemical remission
- Exposure
- CS patients vs obese controls and lean references
- Outcome
- Gut microbiome profile (16S rRNA V3/V4 amplicon sequencing, operational taxonomic units)
Main finding
As reported in the abstract
Gut microbiome profile
- Florid CS vs lean references: disturbed microbial profile
- Microbial dysbiosis of CS maintained after biochemical remission following curative surgery
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Altered Microbiome Signature in Cushing's Syndrome Persists Beyond Remission. J Clin Endocrinol Metab. Published 23 December 2024. doi:10.
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