Long‐Term Cardiovascular Complications in Patients With Pheochromocytomas and Paragangliomas After Surgery: A Large Multi‐Center Study
Authors' conclusion
Long-term cardiovascular complications commonly occur in patients with surgical-cured PPGLs. Pheochromocytomas, had low preoperative LVEF, experienced intraoperative HDI, suffered from postoperative in-hospital cardiovascular complications, and persistent hypertension were determined as the risk factors for long-term cardiovascular complications. These findings may help to improve follow-up management.
Study context
- Population
- Patients who underwent surgery for sporadic pheochromocytomas and paragangliomas (PPGLs) at three centers, January 2012–October 2022
- Participants
- 602 patients
- Exposure
- Pheochromocytomas vs Paragangliomas
- Pheochromocytomasn = 460
- Paragangliomasn = 142
- Outcome
- Incidence of and risk factors for long-term cardiovascular complications after surgery
- Follow-up
- Median 64 months
Methodological detailsmulticentre, three centers
- Multicentre
- Three centers
Main finding
As reported in the abstract
Long-term cardiovascular complications
- Developed long-term cardiovascular complications
- 76 (12.6%)
- Independent risk factor: pheochromocytomas, OR (95% CI 1.425-11.965), p = 0.009
- 4.13
- Independent risk factor: low preoperative left ventricular ejection fraction (LVEF), OR (95% CI 2.141-14.955), p < 0.001
- 5.659
- Independent risk factor: intraoperative hemodynamic instability (HDI), OR (95% CI 1.423-4.385), p = 0.001
- 2.498
- Independent risk factor: postoperative in-hospital cardiovascular complications, OR (95% CI 2.078-15.758), p = 0.001
- 5.723
- Independent risk factor: long-term persistent hypertension, OR (95% CI 1.580-7.988), p = 0.002
- 3.552
Observational data: associations, not effects.
Original publication
Long‐Term Cardiovascular Complications in Patients With Pheochromocytomas and Paragangliomas After Surgery: A Large Multi‐Center Study. Clin Endocrinol (Oxf). Published 18 December 2024. doi:10.
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