Long-term metabolic consequences: persistence of visceral obesity and diabetes mellitus after remission from Cushing’s syndrome
Authors' conclusion
Patients with prior CS remain burdened by adverse metabolic profiles that may contribute to their increased long-term cardiovascular risk.
Study context
- Population
- Patients with cushing's syndrome (CS) from a single tertiary care center, evaluated during active disease and 7 years after biochemical remissionmatched 1:4
- Participants
- 99 vs 396
- Exposure
- Patients with prior CS vs matched population-based controls
- CSn = 99
- Controlsn = 396reference
- Outcome
- Prevalence of T2D, fat distribution and other metabolic characteristics
- Follow-up
- 7 years after remission
Methodological detailssingle tertiary care center, longitudinal, matched controls (age and sex, 1:4)
- Single tertiary care center
- Longitudinal
- Matched controls (age and sex, 1:4)
Main finding
As reported in the abstract
Diabetes prevalence
P < 0.0001
Observational data: associations, not effects.
Further findings
Relative fat mass · 7 years after remission
P = 0.0013
HbA1c · 7 years after remission
P = 0.0087
| Outcome | CS | Controls | P value |
|---|---|---|---|
| WHR · 7 years after remission | 0.89 | 0.82 | P < 0.0001 |
Association with inflammatory markers
- Persistent metabolic alterations were strongly associated with inflammatory markers
Original publication
Long-term metabolic consequences: persistence of visceral obesity and diabetes mellitus after remission from Cushing’s syndrome. Diabetes Res Clin Pract. Published 13 July 2026. doi:10.
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