Increased Salt-Sensitive Blood Pressure in Women vs Men: Is Relative Hyperaldosteronism the Mechanism?
Authors' conclusion
1) Lower Ang II responsiveness in Ang II-targeted organs was observed in men vs women. 2) Similar 24-hour urine ALDO levels in women and men do not support the concept that relative hyper-ALDO is the mechanism for sex difference in SSBP. The data also suggest that the SSBP in women, in some cases, may be benign since it is secondary to a BP reduction on the restricted-salt diet, not an increase on the liberal-salt diet.
Study context
- Population
- Women and men from the HyperPATH cohortHyperPATH cohort
- Participants
- 363 vs 483
- Comparison
- Women vs men
- Womenn = 363
- Menn = 483reference
- Outcome
- Whether women vs men are in a relatively hyper-ALDO state
Main finding
As reported in the abstract
- Women had greater salt-sensitive blood pressure (SSBP), greater aldosterone (ALDO) and vasculature response to Ang II, and higher upright ALDO/PRA
- Men on both restricted- and liberal-salt diets had higher basal supine ALDO, PRA and other ALDO secretagogues
- 24-hour urine ALDO did not differ by sex regardless of salt intake, except in subsets
Further findings
24-hour urine ALDO in subsets
- Normotensive women vs men had greater urine ALDO
- Women vs men younger than 51 had higher urine ALDO
Original publication
Increased Salt-Sensitive Blood Pressure in Women vs Men: Is Relative Hyperaldosteronism the Mechanism? J Clin Endocrinol Metab. Published 19 December 2024. doi:10.
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