Cardiometabolic Outcomes after Surgical Remission of Endogenous Hypercortisolism: A Prospective Cohort Study
Authors' conclusion
Postsurgical improvement of cardiometabolic comorbidities was observed in both patients with CS and MACS. Higher baseline biochemical severity scores were associated with higher postremission improvement in comorbidities.
Study context
- Population
- Adults with Cushing syndrome (CS) or mild autonomous cortisol secretion (MACS) with surgical remission of hypercortisolism (2019–2025); 49% MACS, 36% pituitary CS, 10% adrenal CS, 5% ectopic CS; median age 53 years; 81% women
- Participants
- 357 adults
- Exposure
- CS vs MACS after surgical remission of hypercortisolism
- Outcome
- Changes in severity of hypertension, DM, hyperlipidemia and obesity between baseline, 3 and 12 months postremission
- Follow-up
- 3 and 12 months postremission
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
Improvement in comorbidities · median of 12 months postsurgery
| Group | Value | Improvement in diabetes mellitus (DM) | Improvement in obesity |
|---|---|---|---|
| CS | 70% | 90% (46/51) | 79% (77/97) |
| MACS | 51% | 37% (13/35) | 20% (14/71) |
Value
CS70%
MACS51%
Improvement in diabetes mellitus (DM)
CS90% (46/51)
MACS37% (13/35)
Improvement in obesity
CS79% (77/97)
MACS20% (14/71)
Observational data: associations, not effects.
Further findings
Higher baseline biochemical severity score and improvement in comorbidities (multivariable) · median of 12 months postremission
- Hypertension, OR
- 1.3 (1.1-1.5) (95% CI)
- DM, OR
- 2.5 (1.7-4.1) (95% CI)
- Obesity, OR
- 1.5 (1.2-1.8) (95% CI)
- Multivariable analysis
Baseline comorbidities
- Hypertension
- 336 (94%)
- Obesity
- 241 (68%)
- DM
- 122 (35%)
Original publication
Cardiometabolic Outcomes after Surgical Remission of Endogenous Hypercortisolism: A Prospective Cohort Study. J Clin Endocrinol Metab. Published 29 December 2025. doi:10.
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