Determinants of muscle function and health-related quality of life in patients with endogenous hypercortisolism: a cross-sectional study
Authors' conclusion
Both patients with overt CS and MACS demonstrate reduced muscle strength and low quality of life. The clinical severity score utilized is associated with both physical and psychosocial components of CushingQoL and with the physical component of SF36.
Study context
- Population
- Patients with endogenous hypercortisolism (Cushing syndrome (CS) and mild autonomous cortisol secretion (MACS)), 2019 to 2022; median age 53 years (IQR 42–63), 126 (77%) women
- Participants
- 164 patients
- Exposure
- CS vs MACS vs referent subjects
- MACSn = 81
- Outcome
- Muscle strength: sit-to-stand Z-score
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
MACS
−0.47
mean
CS
−0.54
mean
P = 0.822
- Clinical severity associated with sit-to-stand performance (r)
- −0.22, P = .004
Observational data: associations, not effects.
Further findings
Mean
| Outcome | MACS | CS | P value |
|---|---|---|---|
| SF36 physical component scoreCS vs MACS · lower in CS | 40.5 | 34.0 | P = 0.001 |
| Standardized CushingQoLCS vs MACS · lower in CS | 47.1 | 34.2 | P < 0.001 |
SF36 mental component score
- Similarly low in MACS vs CS
Original publication
Determinants of muscle function and health-related quality of life in patients with endogenous hypercortisolism: a cross-sectional study. Eur J Endocrinol. Published 16 June 2023. doi:10.
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