Duration of adrenal insufficiency after surgical treatment of endogenous hypercortisolism: a prospective cohort study
Authors' conclusion
Baseline clinical and biochemical hypercortisolism severity scores may inform individualized counseling on post-operative AI duration in patients treated for CS and MACS.
Study context
- Population
- Patients with endogenous hypercortisolism (Cushing syndrome (CS) or mild autonomous cortisol secretion (MACS)) treated with surgery who developed postsurgical adrenal insufficiency (AI), 2019–2025; 41% MACS, 46% pituitary CS, 12% adrenal CS, 1% ectopic CS; median age 50 years (IQR: 40–60), 85% women
- Participants
- 242 patients
- Exposure
- MACS vs overt CS
- Outcome
- Duration of post-operative AI (time to recovery of AI)
- Follow-up
- Median 13.7 months (IQR 7.2-26.3)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Median time to recovery of AI
P < 0.001
Observational data: associations, not effects.
Further findings
Factors associated with longer AI duration (multivariable, adjusted for age, sex, body mass index (BMI), glucocorticoid type)
- Moderate to severe biochemical severity score, β
- 11 (P value < .001)
- Moderate to severe clinical severity score, β
- 8.7 (P < .001)
Original publication
Duration of adrenal insufficiency after surgical treatment of endogenous hypercortisolism: a prospective cohort study. Eur J Endocrinol. Published 22 December 2025. doi:10.
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