Bone Mineral Density Improvement After Resolution of Endogenous Cushing Syndrome: A Systematic Review and Meta-Analysis
Authors' conclusion
Our study presents the degree and influencing factors of BMD improvement following eCS resolution. These findings offer guidance for management of eCS-associated osteoporosis.
Study context
- Population
- Patients diagnosed with endogenous CS with lumbar spine or femoral neck bone mineral density (BMD) measured before and after resolution; EMBASE and PubMed to February 2024; mean age 13–44 years, 57%-92% female, follow-up 16–60 months
- Participants
- 302 patients12 studies
- Comparison
- BMD after vs before resolution of endogenous CS
- Outcome
- BMD improvement (lumbar spine and femoral neck) after resolution of eCS
Methodological detailsgeneric inverse variance method, meta-regression
- Generic inverse variance method
- Meta-regression
Pooled result
As reported in the abstract
BMD change after eCS resolution · follow-up 16-60 months
- I2 80.4%
- pooled mean difference, lumbar spine (LS) BMD T-score +0.86 (95% CI 0.51–1.21)
- I2 75.9%
- pooled mean difference, LS BMD Z-score +0.86 (95% CI 0.57–1.16)
- I2 0.0%
- pooled mean difference, femoral neck (FN) BMD T-score +0.38 (95% CI 0.26–0.51)
- I2 20.3%
- pooled mean difference, FN BMD Z-score +0.44 (95% CI 0.31–0.57)
Further pooled results
Meta-regression: factors influencing BMD change
- Factors potentially influencing LS BMD increases: longer follow-up time, higher %female patients and lower mean baseline 24-hour UFC
- None of these factors significantly associated with FN BMD changes
Original publication
Bone Mineral Density Improvement After Resolution of Endogenous Cushing Syndrome: A Systematic Review and Meta-Analysis. Endocr Pract. Published 15 December 2024. doi:10.
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