The Importance of Disease-specific Growth Charts for Children with Congenital Adrenal Hyperplasia
Authors' conclusion
Our study showed that at incremental time points throughout childhood, children with CAH collectively follow specific differences in growth trajectories as compared to unaffected children. These variations highlight the need for CAH-specific charts to assist in clinical management, appraisal of growth trajectories, and assessment of the impact of new therapies.
Study context
- Population
- Patients aged 0 to 20 years with classic CAH due to 21-hydroxylase deficiency, confirmed by hormonal testing and/or CYP21A2 genotyping, from 2 large clinical databases
- Participants
- 515 patients8,692 visits
- Exposure
- CAH patients vs CDC 2000 normative charts
- CAHn = 515
- Outcome
- CAH-specific percentile curves (height-, weight-, BMI-for-age) and differences in incremental growth vs CDC 2000 normative charts
- Follow-up
- 4, 8, 12, 16, and 20 years of age
Methodological details2 large clinical databases, lamda-mu-sigma semiparametric modeling, nodal-point analyses
- 2 large clinical databases
- Lamda-mu-sigma semiparametric modeling
- Nodal-point analyses
Main finding
As reported in the abstract
Growth (height-, weight-, BMI-for-age) channels · 0 to 20 years
- Growth channels of CAH patients significantly different over the entire growing period, with diminished pubertal spurt relative to CDC reference
- 1-sided quantile tests
Observational data: associations, not effects.
Further findings
Age of onset of adiposity rebound (body mass index (BMI)-for-age)
- Earlier in CAH females
- 3.3 years
- Earlier in CAH males
- 3.9 years
- Normative counterparts
- 5-8 years
Original publication
The Importance of Disease-specific Growth Charts for Children with Congenital Adrenal Hyperplasia. J Clin Endocrinol Metab. Published 6 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →