Evaluating Latent Adrenal Insufficiency in Elderly Patients With Nocturnal Hypoglycemia: A Retrospective Observational Study
Main finding · Newly diagnosed and suspected LAIResult — go to the resultOdds ratio 3.26 95% CI 2.59–9.06Authors' conclusion
Diagnosing and treating LAI in the elderly with NH may prevent complications, including fatal diseases, and extend their life expectancy.
Study context
- Population
- Elderly aged >65 years with unassessed latent adrenal insufficiency (LAI), outpatient setting, November 2017–February 2020after propensity matching
- Participants
- 192 elderly
- Exposure
- Nocturnal hypoglycaemia vs no nocturnal hypoglycemia (NH)
- NHn = 96
- non-NHn = 96reference
- Outcome
- Combined prevalence of newly diagnosed and suspected LAI in patients with NH
Methodological detailspropensity-matched, outpatient setting, 1238 elderly assessed; 430 with unassessed LAI monitored by CGM (Freestyle Libre Pro)
- Propensity-matched
- Outpatient setting
- 1238 elderly assessed; 430 with unassessed LAI monitored by CGM (Freestyle Libre Pro)
Main finding
Newly diagnosed and suspected LAI
Odds ratio
3.26
95% CI 2.59–9.06
P < 0.001
Events by group
NHvs non-NH
OR 3.26 (95% CI 2.59–9.06); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Incidence of NH
- Overall incidence rate of NH
- 28.8% (124/430)
Incidence of hypoglycaemia within NH: new-diagnosed LAI vs no LAI
- Patients with new-diagnosed LAI had a higher incidence of hypoglycemia than those without LAI
Original publication
Evaluating Latent Adrenal Insufficiency in Elderly Patients With Nocturnal Hypoglycemia: A Retrospective Observational Study. Endocr Pract. Published 24 October 2024. doi:10.
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