Work Loss and Income Before and After Diagnosis of Addison's Disease: A Population-Based Longitudinal Study
Main finding · Work lossResult — go to the resultMean difference 30.5 days 95% CI 22.9–38.0Authors' conclusion
In AAD, increased work loss and reduced earnings and income were concentrated around diagnosis, peaking in the year after. Reassuringly, both absence from work and income normalized within 4 years following diagnosis.
Study context
- Population
- Working-age individuals (aged 20–62 years) with incident autoimmune Addison's disease (AAD) 2003 to 2019, Swedish Addison Register linked with national health registers, Sweden
- Participants
- 716 vs 3,271
- Exposure
- Autoimmune Addison's disease vs matched general-population comparators
- AADn = 716
- Comparatorsn = 3,271reference
- Outcome
- Annual work loss, taxable earnings and disposable income
- Follow-up
- 10-year period around diagnosis
Methodological detailsnationwide, register-based, matched by sex, age, county, calendar year and education level, longitudinal
- Nationwide
- Register-based
- Matched by sex, age, county, calendar year and education level
- Longitudinal
Main finding
Work loss · year after diagnosis
Mean difference
30.5 days
95% CI 22.9–38.0
AADvs Comparators
mean difference 30.5 days (95% CI 22.9–38.0)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Median difference ($) (95% CI) | P value | |
|---|---|---|---|
| Median taxable earnings · 1 year before diagnosisQuantile regression | −1107 ($−2042 to $−173) | P = 0.02 | |
| Median taxable earnings · 1 year after diagnosisQuantile regression | −1105 ($−2166 to $−43) | P = 0.04 | |
| −3000−2000−100001000Difference, $ (linear scale) |
Disposable income · 1 year after diagnosis
- Disposable income also reduced 1 year after diagnosis, median difference
- $−1084 (95% CI, $−1813 to $−354; P = .004)
- Quantile regression
Original publication
Work Loss and Income Before and After Diagnosis of Addison's Disease: A Population-Based Longitudinal Study. J Clin Endocrinol Metab. Published 30 December 2025. doi:10.
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