Cushing Syndrome Is Associated With a Higher Risk of Cancer—A Nationwide Cohort Study
Authors' conclusion
Patients with endogenous CS have a higher incidence of cancer.
Study context
- Population
- Patients with newly diagnosed endogenous Cushing syndrome (CS) without a history of malignancy, Taiwan, 2006–2017; age at diagnosis 45.3 ± 14.8 years, 80.0% female1,278 identified
- Participants
- 1,246 patients
- Exposure
- Endogenous CS vs general population
- CSn = 1,246
- Outcome
- Age- and sex-standardized incidence rate of all-cause cancer and age-, sex- and calendar year-standardized incidence ratio (SIR) of cancer
Methodological detailsTaiwan National Health Insurance data 2006-2017
- Taiwan National Health Insurance data 2006-2017
Main finding
As reported in the abstract
All-cause cancer incidence
| Group | Value | SIR |
|---|---|---|
| CS | 7.77 per 1000 person-years (95% CI 5.84–10.14) | 2.08 (95% CI 1.54-2.75) |
CS
Value7.77 per 1000 person-years (95% CI 5.84–10.14)
SIR2.08 (95% CI 1.54-2.75)
Observational data: associations, not effects.
Further findings
Standardized incidence of CS · 2006 to 2017
- Age- and sex-standardized incidence of CS decreased (per million person-years)
- 4.84 to 3.77
CS subtype
- Cushing disease
- 35.4%
- Adrenal CS
- 64.6%
Most common cancer types
- Liver
- 27.7%
- Kidney
- 16.7%
- Lung
- 13.0%
Original publication
Cushing Syndrome Is Associated With a Higher Risk of Cancer—A Nationwide Cohort Study. J Clin Endocrinol Metab. Published 13 June 2024. doi:10.
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