Predicting Bilateral Subtypes of Primary Aldosteronism Without Adrenal Vein Sampling: A Systematic Review and Meta-analysis
Authors' conclusion
Despite the variability in published predictive algorithms, they are likely important for decision-making regarding the value of AVS. Prospective validation may enable medical treatment upfront for people with a high likelihood of bilateral PA without the need for an invasive and resource-intensive test.
Study context
- Population
- Published studies of tools predicting bilateral primary aldosteronism (PA) before adrenal vein sampling (AVS) (Medline and Embase)35 studies
- Comparison
- Published algorithms to predict bilateral PA without AVS, grouped into 6 categories
- Outcome
- Sensitivity and specificity of published tools to identify bilateral subtypes of PA
Methodological detailsmeta-regression
- Meta-regression
Pooled result
As reported in the abstract
Sensitivity range across algorithms
5% to 100%
Specificity range across algorithms
36% to 100%
Original publication
Predicting Bilateral Subtypes of Primary Aldosteronism Without Adrenal Vein Sampling: A Systematic Review and Meta-analysis. J Clin Endocrinol Metab. Published 2 August 2023. doi:10.
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