Effects of Isoflavone Interventions on Bone Metabolism in Perimenopausal and Postmenopausal Women: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials
Authors' conclusion
Our findings indicate that isoflavone interventions have the potential to improve BMD at different bone sites, including the lumbar spine, femoral neck, and total hip in perimenopausal and postmenopausal women. Isoflavone may be considered a complementary option in the bone loss of perimenopausal and postmenopausal women.
Study context
- Population
- Perimenopausal and postmenopausal women10 meta-analyses of RCTs
- Comparison
- Isoflavone interventions vs control
- Outcome
- BMD
Methodological detailsrandom-effects model, PRISMA guidelines, Databases searched from inception to August 24, 2023: PubMed, Embase, Cochrane, Web of Science
- Random-effects model
- PRISMA guidelines
- Databases searched from inception to August 24, 2023: PubMed, Embase, Cochrane, Web of Science
Pooled result
As reported in the abstract
Lumbar spine BMD increased with isoflavone, MD
11.50 mg/cm²
95% CI 6.46 to 16.55
Femoral neck BMD increased with isoflavone, MD
2.03%
95% CI 0.57 to 3.50
Top hip BMD increased with isoflavone, MD
0.31%
95% CI 0.03 to 0.59
Original publication
Effects of Isoflavone Interventions on Bone Metabolism in Perimenopausal and Postmenopausal Women: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials. Endocr Pract. Published 28 August 2024. doi:10.
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