Shortened sleep duration impairs adipose tissue adrenergic stimulation of lipolysis in postmenopausal women
Authors' conclusion
SSD blunts adrenergic stimulation of lipolysis without altering insulin-mediated suppression of lipolysis in postmenopausal women. These changes in adipose tissue may potentiate fat gain independent of caloric intake. Therefore, interventions promoting sleep may be considered to mitigate abdominal adiposity in postmenopausal women.
Study context
- Population
- Healthy postmenopausal women; mean (SD) age 59 (4) years, BMI 28.0 (2.6) kg/m²crossover
- Participants
- 9 women
- Comparison
- Shortened sleep duration (SSD) vs habitual sleep, 4 nights each
- Primary endpoint
- Adipose tissue lipolytic capacity (secreted glycerol) and insulin signaling (insulin-mediated Akt phosphorylation)
Methodological detailsex vivo adipose tissue analysis, eucaloric diet
- Ex vivo adipose tissue analysis
- Eucaloric diet
Primary result
As reported in the abstract
- With SSD, basal glycerol secretion was reduced
- With SSD, isoproterenol-stimulated lipolysis was attenuated
- Insulin concentration-dependent increases in phosphorylated Akt seen after habitual sleep were abrogated after SSD
- Insulin-mediated suppression of lipolysis unaltered by sleep duration
Further findings
Global transcription (RNA sequencing)
- Increased transcription of genes involved in adipogenesis and fatty acid metabolism after SSD
Original publication
Shortened sleep duration impairs adipose tissue adrenergic stimulation of lipolysis in postmenopausal women. Obesity (Silver Spring). Published 27 October 2024. doi:10.
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