Reproductive endocrinology

Longitudinal patterns of abdominal visceral and subcutaneous adipose tissue, total body composition, and anthropometric measures in postmenopausal women: Results from the Women’s Health Initiative

Int J Obes (Lond)Published Prospective cohort study

Authors' conclusion

These results demonstrate differences in VAT and SAT according to age, race/ethnicity, time since menopause, and compared to standard measures of body composition in a large and diverse cohort of postmenopausal women.

Study context

Population
Postmenopausal women in the Women's Health Initiative (WHI), US, with DXA scans in the 1990s
Participants
10,184 women
Exposure
Non-Hispanic White vs Non-Hispanic Black vs Hispanic
  • Non-Hispanic Whiten = 7,828
  • Non-Hispanic Blackn = 1,423
  • Hispanicn = 703
Outcome
Longitudinal patterns of change in abdominal adipose tissue (VAT and SAT), overall and by age, race/ethnicity and years since menopause
Follow-up
6 years
Methodological detailslongitudinal, re-analysis of archived DXA scans
  • Longitudinal
  • Re-analysis of archived DXA scans

Main finding

As reported in the abstract

6 years
  • Important differences in VAT and SAT by age and race/ethnicity
  • Women <60 years: VAT increased over follow-up
  • Women ≥70 years: VAT decreased
  • Non-Hispanic Black women had the highest SAT levels
  • Hispanic women had the highest VAT levels
  • Women >10 years since menopause had less SAT, more VAT and a higher VAT/SAT ratio than women <10 years since menopause

Observational data: associations, not effects.

Further findings

Moderate to strong correlation between abdominal adipose tissue and anthropometric measures of body size
Substantial differences in VAT and SAT quantity within BMI and waist circumference categories

Original publication

Longitudinal patterns of abdominal visceral and subcutaneous adipose tissue, total body composition, and anthropometric measures in postmenopausal women: Results from the Women’s Health Initiative. Int J Obes (Lond). Published 4 February 2023. doi:10.1038/s41366-023-01266-9

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