Reproductive endocrinology

Fractures by race and ethnicity in a diverse sample of postmenopausal women: a current evaluation among Hispanic and Asian origin groups

J Bone Miner ResPublished Prospective cohort study

Authors' conclusion

In this diverse sample of postmenopausal women, we confirmed racial and ethnic differences in fracture rates and risk, with novel findings among within Asian and Hispanic subgroups.

Study context

Population
Postmenopausal women, Women's Health Initiative (WHI), 1998–2022
Participants
160,824 women
Exposure
Fracture risk by race and ethnicity, and by Asian and Hispanic origin group
Outcome
Any clinical, hip and major osteoporotic fractures (MOFs)
Follow-up
Median 19.4 (IQR 9.2-24.2) years
Methodological detailsCox proportional hazards model adjusted for age and WHI clinical trial arm
  • Cox proportional hazards model adjusted for age and WHI clinical trial arm

Main finding

As reported in the abstract

median 19.4 years

Any clinical fracture

44.2%

Major osteoporotic fractures (MOFs)

36 278

Hip fractures

8962

Observational data: associations, not effects.

Further findings

Any clinical fracture within Asian origin groups

Filipina vs Japanese women: lower risk of any clinical fracture
24%

Fracture risk within Hispanic origin groups

No differences in fracture risk within Hispanic origin groups

Original publication

Fractures by race and ethnicity in a diverse sample of postmenopausal women: a current evaluation among Hispanic and Asian origin groups. J Bone Miner Res. Published 15 August 2024. doi:10.1093/jbmr/zjae117

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