Reproductive endocrinology

US Adolescents of Asian Ethnicity Have Higher Risk of Polycystic Ovary Syndrome

Horm Res PaediatrPublished Retrospective cohort study

Authors' conclusion

Contemporary US adolescents of South Asian, Filipina, Vietnamese, and Chinese descent have about 2- to 3-fold higher adjusted odds of PCOS than White adolescents, and Hispanic females have 1.5-fold higher odds. These findings emphasize the importance of systematic surveillance in at-risk populations.

Study context

Population
Female adolescents aged 13–17 years with well-child visits 2021–2024 in a California healthcare system
Participants
126,861 adolescents
Exposure
Polycystic ovary syndrome (PCOS) odds by race/ethnicity vs White adolescents
Outcome
Prevalence of diagnosed PCOS by race/ethnicity
Methodological detailssingle healthcare system, logistic regression adjusted for age, body mass index (BMI) category and neighborhood deprivation index (NDI)
  • Single healthcare system
  • Logistic regression adjusted for age, BMI category and NDI

Main finding

As reported in the abstract

Diagnosed PCOS

Hispanic

1.6 to 1.7%

Filipina

1.6 to 1.7%

South Asian

1.6 to 1.7%

NHPI

1.6 to 1.7%

Vietnamese

1.3%

Black

1.1%

White

0.7-0.8%

Chinese

0.7-0.8%

Each group vs whiteAdjusted odds ratio (95% CI)
Vietnamese
3.0(1.7–5.2)
South Asian
2.8(2.0–3.9)
Filipina
2.6(2.0–3.4)
Chinese
1.8(1.2–2.7)
Hispanic
1.5(1.3–1.7)
Overall PCOS prevalence
1.1%

Observational data: associations, not effects.

Further findings

OutcomeValues
PCOS prevalence among adolescents with obesityGroup values printed as shared rangesWhite 2.7 to 3.3% · Black 2.7 to 3.3% · NHPI 2.7 to 3.3% · Hispanic 4.8% · Chinese 5.7-6.2% · Vietnamese 5.7-6.2% · South Asian 5.7-6.2% · Filipina 7.5%
PCOS prevalence among adolescents with obesity — Overall prevalence with obesity
4.1%

Original publication

US Adolescents of Asian Ethnicity Have Higher Risk of Polycystic Ovary Syndrome. Horm Res Paediatr. Published 29 April 2026. doi:10.1159/000552156

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