Adipose Tissue Sex Steroids in Postmenopausal Women With and Without Menopausal Hormone Therapy
Authors' conclusion
Higher local estrogen to androgen ratios and high AT to serum ratios of estrogen concentrations in HT users suggest that HT may significantly influence intracrine sex steroid metabolism in AT; these local changes could be involved in the preventive effect of HT on menopause-associated abdominal adiposity.
Study context
- Population
- Postmenopausal women; serum and subcutaneous and visceral adipose tissue analysed
- Participants
- 63 women
- Exposure
- Per oral MHT users vs nonusers
- Hormone therapy (HT) usersn = 50
- Nonusersn = 13reference
- Outcome
- AT sex steroid concentrations
Main finding
As reported in the abstract
Estrone and estradiol in subcutaneous and visceral adipose tissue (AT) higher in HT users vs nonusers
4- to 7-fold
Testosterone in visceral AT lower in HT users vs nonusers
30%
Estrogen-to-androgen ratios in AT higher in users vs nonusers
4- to 12-fold
Observational data: associations, not effects.
Original publication
Adipose Tissue Sex Steroids in Postmenopausal Women With and Without Menopausal Hormone Therapy. J Clin Endocrinol Metab. Published 10 July 2024. doi:10.
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