Regional Adiposity and Insulin Sensitivity—Interactions With Menopause and HIV in Middle-Aged Black African Women
Authors' conclusion
Insulin sensitivity and beta-cell function were distinctively associated with aSAT and gSAT. While menopause did not influence these relationships, HIV had a significant effect on adipose tissue, characterized by variations in cell size distribution and transcript levels within the depots.
Study context
- Population
- Black South African women from the Middle-Aged Soweto Cohort
- Participants
- 92 women
- Exposure
- Premenopausal vs postmenopausal women, HIV-negative vs living with HIV
- Premenopausal HIV-negativen = 21
- Premenopausal living with HIV (LWH)n = 11
- Postmenopausal HIV-negativen = 42
- Postmenopausal LWHn = 18
- Outcome
- Depot-specific associations between gene expression and SI and beta-cell function (DI)
Main finding
As reported in the abstract
- Pooled model for sensitivity (SI)
- P = .002
- Pooled model for DI
- P = .003
Observational data: associations, not effects.
Further findings
Adipose tissue in women LWH
- Higher adiponectin expression in aSAT with LWH
- P = 0.002
- Lower leptin expression in aSAT with LWH
- P = 0.005
- Higher adiponectin expression in gluteal subcutaneous adipose tissue (gSAT) with LWH
- P = 0.004
- Lower leptin expression in gSAT with LWH
- P = 0.002
- Larger proportion of smaller cells in aSAT with LWH
- P < 0.001
Original publication
Regional Adiposity and Insulin Sensitivity—Interactions With Menopause and HIV in Middle-Aged Black African Women. J Clin Endocrinol Metab. Published 1 July 2024. doi:10.
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