The relationship between male and female endogenous reproductive hormones levels and subjective cognitive decline score: A cross‐sectional analysis of the Pingyin cohort study
Authors' conclusion
There was sex-specific relationship between hormone levels and SCD abnormal. Those with higher testosterone levels in females may increase likelihood of experiencing SCD. Males with higher testosterone levels and higher testosterone/E2 ratio may be associated with reduced likelihood of SCD. The roles of endogenous reproductive hormone levels and their dynamic changes in cognitive function need further investigation.
Study context
- Population
- Adults aged 45–70 years, Pingyin cohort; 66.1% female, mean age 59.1 (SD 7.1) years; E2, testosterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) measured in females, E2 and testosterone in males1,285 female
- Participants
- 1,943 adults
- Exposure
- High vs low endogenous reproductive hormone levels, by sex
- Outcome
- SCD status by subjective cognitive decline questionnaire (SCD-Q9) score
Methodological detailsbaseline data from the Pingyin cohort study
- Baseline data from the Pingyin cohort study
Main finding
As reported in the abstract
SCD
High vs LowOdds ratio (95% CI)
Women, testosterone
1.43(1.01–2.05)
Men, testosterone; decreased chance of SCD
0.59(0.35–0.98)
Men, testosterone/E2 ratio; decreased chance of SCD
0.55(0.33–0.90)
Observational data: associations, not effects.
Further findings
Subjective cognitive decline (SCD) score per one-unit increase of testosterone, males
- β (95% CI)
- −.029 (−0.052, −0.007)
- Multivariable linear regression
Original publication
The relationship between male and female endogenous reproductive hormones levels and subjective cognitive decline score: A cross‐sectional analysis of the Pingyin cohort study. Clin Endocrinol (Oxf). Published 1 July 2024. doi:10.
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