Bone health in complete androgen insensitivity syndrome: a comprehensive assessment in a large adult cohort
Authors' conclusion
Young adults with CAIS show impaired lumbar BMD and a notable prevalence of fragility fractures, with similar findings across gonadectomy status and HRT regimen.
Study context
- Population
- Adult women with complete androgen insensitivity syndrome (CAIS), age 34 ± 8.7 years
- Participants
- 46 women
- Exposure
- Gonadectomized vs with gonads; Hormonal replacement therapy (HRT) regimens
- Gonadectomizedn = 41
- With gonadsn = 5
- Outcome
- Bone health: BMD by DXA, vertebral morphometry, bone turnover markers
Methodological detailsmonocentric
- Monocentric
Main finding
As reported in the abstract
Bone health
- Lumbar spine bone mineral density (BMD) Z-score (mean ± SD), impaired in both groups
- −1.78 ± 1
- Lumbar spine Z-score <−2, % of cohort
- 47.8%
- Total hip BMD Z-score
- −0.6 ± 1
- Femoral neck BMD Z-score
- −0.77 ± 1
- Fragility fracture rate (median age 39 years)
- 8.7%
Observational data: associations, not effects.
Further findings
BMD across HRT regimens
- No significant differences among HRT regimes
Expanded sub-analysis incl. 27 retrospective individuals: BMD across HRT regimens
- No significant differences in BMD across HRT regimes
- n = 73
Original publication
Bone health in complete androgen insensitivity syndrome: a comprehensive assessment in a large adult cohort. Eur J Endocrinol. Published 7 August 2026. doi:10.
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