Risk Factors for Pituitary Adenoma Development in Multiple Endocrine Neoplasia Type 1: A Nationwide Study of 240 Cases
Authors' conclusion
Risk of PA in MEN1 clusters at younger ages and declines thereafter. Prior primary hyperparathyroidism, non-missense MEN1 PVs, and female sex further mark higher-risk profiles. These findings may help personalize PA follow-up-prioritizing closer imaging in early adulthood and allowing longer intervals when baseline imaging is normal and additional risk markers are absent-pending validation in larger multicenter studies.
Study context
- Population
- MEN1 patients, 55.8% female
- Participants
- 240 patients
- Outcome
- PA development
Methodological detailsnationwide, multicenter
- Nationwide
- Multicenter
Main finding
As reported in the abstract
Independent factors for PA development (full cohort, Cox regression)
Pituitary adenomas (PAs) detected
112
46.6%
Observational data: associations, not effects.
Further findings
PA characteristics
- Mean age at PA detection, years
- 36.1 ± 13.9
- Diagnosed through screening
- 63.3%
- Prolactinomas
- 49.1%
- Microadenomas
- 62.5%
Independent factors in prospectively screened subgroup (n = 199)
- The same factors remained significant in the screened subgroup
Original publication
Risk Factors for Pituitary Adenoma Development in Multiple Endocrine Neoplasia Type 1: A Nationwide Study of 240 Cases. J Clin Endocrinol Metab. Published 8 September 2025. doi:10.
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