Radiological Surveillance for Pituitary Adenomas in Multiple Endocrine Neoplasia Type 1: A Longitudinal Cohort Study
Authors' conclusion
In an overwhelming majority of patients with MEN1, radiological surveillance for nonfunctional pituitary adenomas offers minimal added benefit beyond patient-reported symptoms and pituitary function testing.
Study context
- Population
- Patients with genetically confirmed MEN1 evaluated at the NIH Clinical Center between 1977 and September 2024mean follow-up 14 ± 12 years
- Participants
- 320 patients
- Outcome
- Cumulative proportion and rate of intervention for nonfunctional adenomas
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Patients with nonfunctional adenomas needing intervention
21 of 95
22%
Rate of intervention per 100 patient-years for nonfunctional adenomas
3.1%
CI 2.0–4.7%
Observational data: associations, not effects.
Further findings
Prevalence of pituitary adenomas
- Pituitary adenomas
- 182/320 (57%)
- Nonfunctional adenomas among adenomas
- 95/182 (52%)
Tumor volume stability of nonfunctional adenomas · mean 8.3 ± 6.1 years
- Remained stable
- 38/48 (79%)
Magnetic resonance imaging (MRIs) for nonfunctional adenomas prompted by clinical or biochemical abnormalities
- Prompted MRIs
- 42/518 (8.1%)
- MRIs avoidable with individualized imaging per patient with nonfunctional microadenoma
- ≈4
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →