Health-related quality of life in children with multiple endocrine neoplasia (MEN) and their siblings
Authors' conclusion
Overall, children with MEN reported HRQoL comparable to siblings and age-matched Dutch norms, except for reduced physical functioning in MEN2B. Clinical manifestations negatively affected physical, social, and school functioning
Study context
- Population
- Children and adolescents with genetically confirmed MEN1, MEN2A and MEN2B and their siblings; Health-Related Quality of Life (HRQoL) by PedsQL self-report and parent-proxy report
- Participants
- 77 vs 26
- Exposure
- Children with MEN vs siblings without MEN and healthy Dutch norms
- MENn = 77
- Siblingsn = 26reference
- Outcome
- HRQoL (PedsQL)
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
HRQoL
- Children with MEN1 and MEN2A reported HRQoL comparable to siblings and healthy Dutch norms
- Only children with MEN2B showed significantly lower physical HRQoL
Observational data: associations, not effects.
Further findings
Gender and age effects
- No gender or age effects were observed
Parent-proxy vs child self-report
- Parent-proxy scores significantly higher than child self-reports on all domains except emotional functioning
Clinical MEN-related manifestations (MEN1 and MEN2B)
- Children with clinical manifestations had significantly lower physical, social and school functioning scores than those without
Original publication
Health-related quality of life in children with multiple endocrine neoplasia (MEN) and their siblings. J Clin Endocrinol Metab. Published 4 March 2026. doi:10.
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