Sexual Function and Depressive Symptoms in Premenopausal Women with Differentiated Thyroid Cancer: A Cross-Sectional Study
Authors' conclusion
Sexual dysfunction and depressive symptoms were more frequent in women with DTC than in healthy controls; moreover, among women with DTC, the greatest deterioration was seen in those receiving stronger TSH suppression.
Study context
- Population
- Premenopausal women with differentiated thyroid carcinoma (DTC) on stable TSH suppression therapy, and healthy controls
- Participants
- 110 vs 40
- Exposure
- Premenopausal women with DTC on TSH suppression therapy vs healthy controls
- DTCn = 110
- Healthy controlsn = 40reference
- Outcome
- FSD (FSFI) and depressive symptoms (BDI-II)
Main finding
As reported in the abstract
Values
Depressive symptoms
Observational data: associations, not effects.
Further findings
Correlations of Beck Depression Inventory-II (BDI-II), thyroid hormones and antibodies with Female Sexual Function Index (FSFI) and depression
- Increased BDI-II scores inversely correlated with FSFI total and subdomain scores (desire, satisfaction, pain)
- TSH levels positively associated with FSFI scores; FT4 and FT3 inversely correlated with satisfaction and lubrication
- Elevated thyroglobulin antibody levels associated with higher depression scores
Independent associations with female sexual dysfunction (FSD) (logistic regression)
- Suppressed TSH and higher BDI-II scores independently associated with higher odds of FSD
- Multivariable models adjusted for age
Original publication
Sexual Function and Depressive Symptoms in Premenopausal Women with Differentiated Thyroid Cancer: A Cross-Sectional Study. Thyroid. Published 27 February 2026. doi:10.
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