Clinical profile and treatment outcomes among patients with sporadic and multiple endocrine neoplasia syndrome‐related primary hyperparathyroidism
Authors' conclusion
Patients with MPHPT have more severe, frequent and early onset of bone and renal involvement despite milder biochemical features. A normal serum ALP, low BMD for age and gender at lumbar spine and histopathology evidence of hyperplasia are predictive factors for MEN1 syndrome in PHPT.
Study context
- Population
- Patients with PHPT evaluated at the endocrine clinic of All India Institute of Medical Sciences, New Delhi, India, January 2015–December 2021
- Participants
- 23 vs 251
- Exposure
- MEN1-related PHPT vs sporadic PHPT
- MPHPTn = 23
- SPHPTn = 251reference
- Outcome
- Clinical, biochemical and radiological features, and predictors of MEN1 in PHPT
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Prevalence of MEN1 syndrome among PHPT
8.2%
Genetic mutation identified by Sanger sequencing in MPHPT
26.1%
Observational data: associations, not effects.
Further findings
Predictors of MPHPT (multivariable analysis)
- Hyperplasia on histopathology, OR
- 40.1 (p < .001)
- Alkaline phosphatase (ALP) within reference range, OR
- 5.6 (p = .02)
- Lumbar spine bone mineral density (BMD), OR per unit increase in Z score
- 0.39 (p < .001)
- Multivariable analysis
Original publication
Clinical profile and treatment outcomes among patients with sporadic and multiple endocrine neoplasia syndrome‐related primary hyperparathyroidism. Clin Endocrinol (Oxf). Published 1 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →