Trabecular Bone Score as a More Sensitive Tool to Evaluate Bone Involvement in MEN1-related Primary Hyperparathyroidism
An erratum to this article was published (J Clin Endocrinol Metab, 12 Jul 2024 ↗)
Authors' conclusion
The cancellous bone microarchitecture was more severely damaged in patients with MHPT according to TBS, which suggested that TBS could be a sensitive supplemental index in addition to BMD to identify bone-involvement risk in patients with MHPT.
Study context
- Population
- Patients with MEN1-related or sporadic PHPT; DXA in a subgroup of MHPT compared with SHPT86 MHPT with bone mineral density (BMD) data
- Participants
- 120 vs 360
- Exposure
- MEN1-related PHPT vs sporadic PHPT
- MHPTn = 120
- SHPTn = 360reference
- Outcome
- Clinical characteristics, especially skeletal involvement (lumbar spine BMD and TBS)
Methodological detailscomparative
- Comparative
Main finding
As reported in the abstract
| Group | Value | Trabecular bone score (TBS) |
|---|---|---|
| MHPT | 0.91 ± 0.18 g/cm² | 1.22 ± 0.14 |
| SHPT | 1.01 ± 0.17 g/cm² | 1.29 ± 0.11 |
Value
MHPT0.91 ± 0.18 g/cm²
SHPT1.01 ± 0.17 g/cm²
Trabecular bone score (TBS)
MHPT1.22 ± 0.14
SHPT1.29 ± 0.11
- MHPT vs SHPT: P < 0.001 — BMD and TBS lower with MHPT
- MHPT with normal BMD with bone microstructure damage by TBS
- 15 of 34
Observational data: associations, not effects.
Further findings
| Outcome | MHPT | SHPT | P value |
|---|---|---|---|
| Age at hospital visitLower with MHPT | 43.5 (IQR 31.5–52.0) | 52.0 (IQR 40.5–61.0) | P < 0.001 |
Age at hospital visit
- Disease duration longer in MHPT
Proportion of skeletal involvement (all patients)
- Significantly lower in MHPT
Original publication
Trabecular Bone Score as a More Sensitive Tool to Evaluate Bone Involvement in MEN1-related Primary Hyperparathyroidism. J Clin Endocrinol Metab. Published 4 August 2023. doi:10.
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