Is Multifocality a Predictor of Poor Outcome in Childhood and Adolescent Papillary Thyroid Carcinoma?
Authors' conclusion
MFD was less common in childhood and adolescent patients with PTC than adults and was not a predictor of poor outcome on multivariate analysis, with excellent long-term outcomes in all patients with PTC. MFD does not appear to warrant completion thyroidectomy in childhood and adolescent patients selected for lobectomy.
Study context
- Population
- Patients with papillary thyroid carcinoma (PTC) undergoing surgery (1986–2021) at Memorial Sloan Kettering Cancer Center
- Exposure
- Multifocal (multifocal disease (MFD)) vs unifocal disease (UFD) in childhood and adolescent PTC; childhood and adolescent vs adult PTC
- Childhood and adolescentn = 283
- Adultsn = 5,564reference
- Outcome
- Incidence of MFD in childhood and adolescent vs adult PTC, and whether MFD predicts poorer outcomes in childhood and adolescent PTC
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Incidence of MFD
P = 0.002
Observational data: associations, not effects.
Further findings
Outcomes of MFD vs UFD in childhood and adolescent PTC · median follow-up 68 months
- Overall survival in both groups
- 100%
- Similar tumor stage and PTC subtype; no significant difference in histopathologic features
- No significant difference in 5-year recurrence-free probability
- No significant difference in 5-year contralateral lobe PTC-free probability after lobectomy
- MFD not a predictor for recurrence on multivariate analysis
Original publication
Is Multifocality a Predictor of Poor Outcome in Childhood and Adolescent Papillary Thyroid Carcinoma? J Clin Endocrinol Metab. Published 23 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →