Traits of Patients With Pituitary Tumors in Multiple Endocrine Neoplasia Type 1 and Comparing Different Mutation Status
Authors' conclusion
This is the first study comparing characteristics of patients with MEN1 with and without PITs harboring different mutations. Patients without MEN1 mutations tended to have less organ involvement and it might be reasonable for them to receive less intensive follow-up.
Study context
- Population
- Patients with MEN1 at a tertiary referral center, 2010–2023
- Participants
- 42 patients
- Exposure
- MEN1 patients with vs without pituitary tumors (PITs); mutation+/PIT+ vs mutation-/PIT+
- PIT+n = 24
- Outcome
- Characteristics of MEN1 patients with PITs and by mutation status
Methodological detailssingle-centre, tertiary referral center
- Single-centre
- Tertiary referral center
Main finding
As reported in the abstract
- Patients with PITs
- 24
- Invasive PITs managed with transsphenoidal surgery
- 3
- PIT enlarged during follow-up
- 1
- MEN1 mutations identified
- 57.1%
- Novel mutations
- 5
Observational data: associations, not effects.
Original publication
Traits of Patients With Pituitary Tumors in Multiple Endocrine Neoplasia Type 1 and Comparing Different Mutation Status. J Clin Endocrinol Metab. Published 30 June 2023. doi:10.
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