Prepubertal Children With Obesity Have High Free IGF-1 Levels and Accelerated Growth Despite Reduced Pappalysin Levels
Authors' conclusion
Increased circulating total and free IGF-I, insulin, and IGF-II may all contribute to the increased rate of prepubertal growth and bone maturation observed in children with obesity, with STC2 possibly being involved.
Study context
- Population
- Prepubertal children with severe obesity (50% males/females, age 7.72 ± 2.05 years, body mass index (BMI) z-score 4.95 ± 1.70, height z-score 1.28 ± 1.04), studied at diagnosis and after ≥0.5 BMI z-score reduction
- Participants
- 150 vs 206
- Comparison
- Prepubertal children with severe obesity vs healthy controls; at diagnosis vs after weight loss
- Obesityn = 150
- Controlsn = 206reference
- Outcome
- Serum pappalysins, stanniocalcins and GH-IGF axis components, obesity vs controls
- Follow-up
- At diagnosis
Methodological detailsage- and sex-matched controls, before-and-after weight reduction
- Age- and sex-matched controls
- Before-and-after weight reduction
Main finding
As reported in the abstract
- Decreased serum PAPP-A, PAPP-A2 and STC2 in obesity
- Increased total and free IGF-I, intact IGFBP-3, acid-labile subunit (ALS), IGF-II and insulin in obesity
- No difference in free IGF-I/total IGF-I ratio
Observational data: associations, not effects.
Further findings
Correlation of BMI and height with biochemical parameters
- Neither standardized BMI nor height correlated with any biochemical parameter analysed
Changes after weight loss · after ≥0.5 BMI z-score reduction
- Decrease in IGF-II, insulin and ALS; increase in IGFBP-2 and −5, STC2 and PAPP-A
Original publication
Prepubertal Children With Obesity Have High Free IGF-1 Levels and Accelerated Growth Despite Reduced Pappalysin Levels. J Clin Endocrinol Metab. Published 25 April 2024. doi:10.
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