Joint Effects of Long‐Term Obesity and Genetic Susceptibility on Sex‐Specific Brain Aging
Authors' conclusion
These findings underscore long-term obesity as a critical, sex-dimorphic driver of accelerated brain aging
Study context
- Population
- UK Biobank participants with multimodal brain age estimates and 16-year longitudinal obesity trajectoriesUK Biobank
- Participants
- 35,092 participants
- Exposure
- Obesity trajectories and polygenic risk vs lower-risk categories
- Malesn = 16,484
- Femalesn = 18,608
- Outcome
- Brain age acceleration (sex-specific XGBoost multimodal brain age)
Methodological detailsUK Biobank, sex-specific analyses
- UK Biobank
- Sex-specific analyses
Main finding
As reported in the abstract
Odds ratio (95% CI)
High-stable obesity (males)
1.90(1.64–2.21)
High-stable obesity (females)
1.25(1.12–1.40)
OR
- High genetic risk (males)
- 1.39
- High genetic risk (females)
- 1.34
- High genetic risk + high-stable obesity (males)
- 2.78
- High genetic risk + high-stable obesity (females)
- 1.57
- Shifting from obesity to non-obesity reduced risk in males
- 30%
- Shifting from obesity to non-obesity reduced risk in females
- 18%
Observational data: associations, not effects.
Original publication
Joint Effects of Long‐Term Obesity and Genetic Susceptibility on Sex‐Specific Brain Aging. Obesity (Silver Spring). Published 6 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →