Polygenic score for body mass index in relation to mortality among patients with renal cell cancer
Main finding · All-cause mortality, BMI PGSResult — go to the resultHazard ratio 0.98 95% CI 0.88,1.10Authors' conclusion
We found no association between either genetic variants for high BMI or measured pre-diagnostic body adiposity and mortality among RCC patients, and our results suggested a role for reverse causation in the association of obesity with lower mortality. Future studies should be designed carefully to produce unbiased estimates that account for confounding and reverse causation.
Study context
- Population
- Renal cell cancer (RCC) patients in the UK Biobank446 deaths
- Participants
- 1,264 patients
- Exposure
- Body mass index (BMI) polygenic score (PGS), measured pre-diagnostic BMI and waist-to-hip ratio (WHR) in relation to mortality
- Outcome
- All-cause mortality by BMI PGS
Methodological detailspolygenic score (336 BMI-associated genetic variants), UK Biobank
- Polygenic score (336 BMI-associated genetic variants)
- UK Biobank
Main finding
All-cause mortality, BMI PGS
Hazard ratio
0.98
95% CI 0.88,1.10
BMI PGS per SD increase
HR 0.98 (95% CI 0.88,1.10)
Per SD increase, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Mortality, measured pre-diagnostic BMI and WHR (incident cases)BMI per 5 kg/m² increase | 0.93 (0.83,1.04) | |
| Mortality, measured pre-diagnostic BMI and WHR (incident cases)WHR per 0.1 increase | 0.97 (0.83,1.13) | |
| Mortality, anthropometrics measured within 2 years before RCC diagnosisBMI per 5 kg/m² | 0.76 (0.59,0.98) | |
| Mortality, anthropometrics measured within 2 years before RCC diagnosisWHR per 0.1 increase | 0.67 (0.45,0.98) | |
| 0.512Hazard ratio (log scale) |
RCC-specific mortality
- Similar patterns were observed for RCC-specific mortality
Original publication
Polygenic score for body mass index in relation to mortality among patients with renal cell cancer. Int J Obes (Lond). Published 17 August 2024. doi:10.
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