Liver Fat Accumulation Is Associated With Increased Insulin Secretion Independent of Total, Visceral, and Pancreatic Fat
Authors' conclusion
Accumulation of liver fat is associated with increased insulin secretion independently of total adiposity, abdominal fat distribution, and pancreatic fat. Thereby, hyperinsulinemia in fatty liver disease is partly because of insulin hypersecretion and partly because of impaired insulin clearance.
Study context
- Population
- Men with abdominal obesity, balanced on body mass index (BMI), total body fat, visceral adipose tissue (VAT) and pancreatic fatmen with abdominal obesity
- Participants
- 61 men
- Exposure
- High liver fat vs low liver fat
- High liver fat (HLF)n = 28
- Low liver fat (LLF)n = 33reference
- Outcome
- Insulin secretion and insulin sensitivity indices from a frequently sampled 5-hour OGTT (11 samples) with oral minimal model
Methodological detailsgroups balanced on BMI, total body fat, VAT and pancreatic fat
- Groups balanced on BMI, total body fat, VAT and pancreatic fat
Main finding
As reported in the abstract
Insulin secretion (HLF vs LLF)
Fasting insulin secretion rate greater with HLF
≈37%
Total postprandial insulin secretion rate greater with HLF
≈50%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| AUC (5-hour) for glucose, insulin and C-peptide · greater with HLF | all P < .05 |
| Insulin sensitivity, disposition index and insulin clearanceLower with HLF | all P < .05 |
- AUC (5-hour) for glucose, insulin and C-peptide — Glucose AUC greater with HLF
- ∼10%
- AUC (5-hour) for glucose, insulin and C-peptide — Insulin AUC greater with HLF
- ∼38%
- AUC (5-hour) for glucose, insulin and C-peptide — C-peptide AUC greater with HLF
- ∼28%
Fasting glucose, insulin, C-peptide, TG, HDL-C, HbA1c
- Significantly greater fasting glucose, insulin, C-peptide and TG and lower HDL-C with HLF; similar HbA1c
Insulin sensitivity, disposition index and insulin clearance
- Lower whole-body and hepatic insulin sensitivity, disposition index and total insulin clearance with HLF
Original publication
Liver Fat Accumulation Is Associated With Increased Insulin Secretion Independent of Total, Visceral, and Pancreatic Fat. J Clin Endocrinol Metab. Published 16 August 2024. doi:10.
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