Relationship between changes in the triglyceride glucose-body mass index and frail development trajectory and incidence in middle-aged and elderly individuals: a national cohort study
An erratum to this article was published (Cardiovasc Diabetol, 30 Jan 2025 ↗)
Authors' conclusion
A higher TyG-BMI is associated with the rapid development of FI trajectory and a greater frail risk. However, excessively low TyG-BMI levels also appear to contribute to frail development. Maintaining a healthy TyG-BMI, especially a healthy BMI, may help prevent or delay the frail onset.
Study context
- Population
- Middle-aged and elderly individuals in the China Health and Retirement Longitudinal Study (2011–2020)
- Participants
- 9,135 participants
- Exposure
- Higher vs lower baseline, change and cumulative triglyceride glucose-body mass index (TyG-BMI) categories
- Outcome
- Rapid FI trajectory and frail incidence
- Follow-up
- Nine years
Methodological detailsnational cohort, CHARLS 2011-2020
- National cohort
- CHARLS 2011-2020
Main finding
As reported in the abstract
Rapid FI trajectory
- Baseline TyG-BMI Q3: OR
- 1.25 (1.10-1.42) (95% CI)
- Baseline TyG-BMI Q4: OR
- 1.83 (1.61-2.09) (95% CI)
- Consistently second to highest TyG-BMI change: OR
- 1.49 (1.32-1.70) (95% CI)
- Highest TyG-BMI change: OR
- 2.17 (1.84-2.56) (95% CI)
- Cumulative TyG-BMI Q3: OR
- 1.20 (1.05-1.36) (95% CI)
- Cumulative TyG-BMI Q4: OR
- 1.94 (1.70-2.22) (95% CI)
Observational data: associations, not effects.
Further findings
Frail incidence
- Baseline TyG-BMI Q4: HR
- 1.42 (1.28-1.58) (95% CI)
- Consistently second to highest TyG-BMI change: HR
- 1.23 (1.12-1.34) (95% CI)
- Highest TyG-BMI change: HR
- 1.58 (1.42-1.77) (95% CI)
- Cumulative TyG-BMI Q3: HR
- 1.10 (1.00-1.21) (95% CI)
- Cumulative TyG-BMI Q4: HR
- 1.46 (1.33-1.60) (95% CI)
Frailty index (FI) progression speed
- Persistently second-lowest, second-highest and highest TyG-BMI change: β
- 0.15, 0.38 and 0.76
- Cumulative TyG-BMI Q3 and Q4: β
- 0.25 and 0.56
Nonlinear association
- U-shaped association between TyG-BMI and both rapid FI trajectory and higher frail risk; BMI the primary factor
Original publication
Relationship between changes in the triglyceride glucose-body mass index and frail development trajectory and incidence in middle-aged and elderly individuals: a national cohort study. Cardiovasc Diabetol. Published 16 August 2024. doi:10.
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