Pituitary deficiencies related to optic nerve hypoplasia and visual acuity
Main finding · Any pituitary deficiencyResult — go to the resultodds 4.9 95% CI 2.4–10.1Authors' conclusion
This study shows a significant association between severity of visual impairment and increased probability of pituitary deficiencies in children with bONH versus uONH. Children with ONH require urgent endocrine evaluation due to risk of pituitary deficiencies, but risk stratification may also be based on severity of visual impairment.
Study context
- Population
- Patients with optic nerve hypoplasia seen at a single center, 2013–2022
- Participants
- 197 patients
- Exposure
- Bilateral optic nerve hypoplasia (ONH) vs unilateral ONH
- Outcome
- Pituitary deficiencies (number and age of development) in relation to visual acuity
Methodological detailsretrospective chart review, single-centre
- Retrospective chart review
- Single-centre
Main finding
Any pituitary deficiency
odds
4.9
95% CI 2.4–10.1
As reported in the abstract
Observational data: associations, not effects.
Further findings
First presenting pituitary deficiency
- Central hypothyroidism was the most common first presenting deficiency, followed by GH, across all patients
Original publication
Pituitary deficiencies related to optic nerve hypoplasia and visual acuity. Clin Endocrinol (Oxf). Published 4 August 2024. doi:10.
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