Pituitary Magnetic Resonance Imaging as a Prognostic Factor of Pituitary Insufficiency—The Follow‐Up Analysis of a Cohort of Children With Pituitary Stalk Interruption Syndrome
Authors' conclusion
The absence of the pituitary stalk may serve as a sensitive marker of CPHD, whereas the absence of the posterior pituitary appears to predispose patients to AVPD. Additionally, the coexistence of ONH and PSIS may be associated with greater severity of anterior pituitary hormonal dysfunction.
Study context
- Population
- Children diagnosed with pituitary stalk interruption syndrome (PSIS)
- Participants
- 50 children
- Exposure
- Pituitary MRI features and pituitary hormone deficiencies
- Outcome
- Correlation between MRI features and pituitary hormonal profile; MRI as prognostic factor of pituitary insufficiency
- Follow-up
- Median 5.9 years
Methodological detailsretrospective data before 2016, prospective thereafter, follow-up analysis
- Retrospective data before 2016, prospective thereafter
- Follow-up analysis
Main finding
As reported in the abstract
Progression to combined pituitary hormone deficiency (CPHD)
P = 0.013
- Isolated pituitary hormone deficiencies at initial diagnosis
- 32 patients (64%)
- Developed additional deficits during follow-up (of those with isolated deficiencies)
- 15 (47%)
- Combined pituitary hormone deficiency (CPHD) prevalence, initial to follow-up
- 16 (32%) to 31 patients (62%)
- Only initial isolated growth hormone deficiency (GHD) persisted
- 17 patients (34%)
- All arginine vasopressin deficiency (AVPD) cases only in patients with absent posterior pituitary (Fisher's exact test p < 0.000001)
- OR = 0, 95% CI 0-0.04
Observational data: associations, not effects.
Original publication
Pituitary Magnetic Resonance Imaging as a Prognostic Factor of Pituitary Insufficiency—The Follow‐Up Analysis of a Cohort of Children With Pituitary Stalk Interruption Syndrome. Clin Endocrinol (Oxf). Published 17 March 2026. doi:10.
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