Clinical Outcomes Following Supply‐Driven Transition From Intranasal to Oral Desmopressin in AVP‐Deficiency—A Single Centre Experience Including The Pituitary Foundation Desmopressin Shortage Impact Report
Authors' conclusion
45.2% (19/42) of patients achieved adequate symptom control post-switch with varying conversion ratios, and over half (13/23, 56.5%) of patients switched with an initial 1:10 conversion ratio reported symptomatic recurrence.
Study context
- Population
- Patients with confirmed arginine vasopressin deficiency (AVP-D) switched from intranasal to oral desmopressin after national suspension of intranasal desmopressin, tertiary UK centre (01/01/2025–01/07/2025); mean age 52.6 ± 2.3, 31% male
- Participants
- 42 patients
- Exposure
- Intranasal to oral desmopressin switch: initial 1:10 ratio vs median 1:20 ratio
- 1:10 ration = 23
- 1:20 ration = 19
- Outcome
- Symptomatic recurrence after switch, warranting further titration
Methodological detailssingle-centre, tertiary centre
- Single-centre
- Tertiary centre
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Desmopressin dose
Mcg/day
- Intranasal dose pre-switch, median (IQR 10-20 mcg)
- 10
- Initial oral dose before titration, median (IQR 100-200 mcg)
- 200
- Final oral dose after titration, median (IQR 162.5-300 mcg)
- 200
Healthcare use after switch
- Patient calls
- 16
- Additional blood tests
- 79
- Hospitalisations
- 1
The Pituitary Foundation Impact Report (national patient-reported data)
- Poorer symptomatic control post-switch
- 121/161 (75.2%)
- Requiring additional endocrine input
- 76/161 (47.2%)
Safety
Hospitalisation after switch
- Hospitalisation
- 1
Original publication
Clinical Outcomes Following Supply‐Driven Transition From Intranasal to Oral Desmopressin in AVP‐Deficiency—A Single Centre Experience Including The Pituitary Foundation Desmopressin Shortage Impact Report. Clin Endocrinol (Oxf). Published 12 March 2026. doi:10.
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