Oxidative phosphorylation patterns in pituitary adenoma/neuroendocrine tumors
Authors' conclusion
PitNETs/adenomas display lineage-specific and highly heterogeneous OXPHOS-system phenotypes. Complex I deficiency and mtDNA mutations occur not only in genomically stable gonadotroph tumors/adenomas but also in highly disrupted corticotroph tumors/adenomas with a near-haploid genome.
Study context
- Population
- 43 previously molecularly and histologically classified pituitary neuroendocrine tumors (PitNETs)/adenomasmtDNA sequenced in 21
- Participants
- 43 participants
- Comparison
- PitNETs/adenomas vs normal adenohypophyseal tissue; across PitNET lineages
- Outcome
- Expression patterns of oxidative phosphorylation (OXPHOS) system subunits across PitNET/adenoma lineages
Methodological detailsimmunohistochemistry, mtDNA sequencing
- Immunohistochemistry
- mtDNA sequencing
Main finding
As reported in the abstract
OXPHOS phenotypes
Corticotroph tumors/adenomas with near-haploid genomes harbouring disruptive complex I mutations
2
Staining heterogeneity, incl. focal expression loss (especially SF1-lineage and all mtDNA-mutated tumors)
24 of 43
Original publication
Oxidative phosphorylation patterns in pituitary adenoma/neuroendocrine tumors. Pituitary. Published 11 March 2026. doi:10.
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