Intranasal povidone-iodine concentration and olfactory recovery after endoscopic endonasal pituitary surgery
Authors' conclusion
Both 10% and 1% PVP-I solutions were associated with excellent antiseptic outcomes. Patients receiving 1% PVP-I had better postoperative olfactory recovery than those receiving 10% PVP-I.
Study context
- Population
- Patients with sellar tumors undergoing endoscopic endonasal pituitary surgery, Mackay Memorial Hospital (August 2015-March 2022); 57 with pituitary adenomas
- Participants
- 65 patients
- Exposure
- 10% PVP-I vs 1% PVP-I for intranasal antisepsis
- 10% PVP-In = 17
- 1% PVP-In = 48reference
- Outcome
- Postoperative olfactory recovery (Taiwan Smell Identification Test, Taiwan Smell Identification Test (TWSIT))
- Follow-up
- 1, 3 and 6 months postoperatively
Methodological detailssingle-centre, 10% PVP-I used during COVID-19 pandemic
- Single-centre
- 10% PVP-I used during COVID-19 pandemic
Main finding
As reported in the abstract
TWSIT score · 6 months
10% PVP-I
35.9
mean · ± 9.5
1% PVP-I
40.5
± 8.7
P = 0.01
- 10% PVP-I: significant decrease from baseline
- P = 0.03
- 1% PVP-I: no significant difference from baseline
- P = 0.85
Observational data: associations, not effects.
Further findings
| Outcome | 10% PVP-I | 1% PVP-I | P value |
|---|---|---|---|
| Preoperative TWSIT score · baselineComparable | 41.2 ± 5.9 | 40.9 ± 7.0 | P = 0.81 |
Safety
Events
| Outcome | 10% PVP-I | 1% PVP-I |
|---|---|---|
| Postoperative wound infection or meningitis · follow-up | 0 | 0 |
Original publication
Intranasal povidone-iodine concentration and olfactory recovery after endoscopic endonasal pituitary surgery. Pituitary. Published 9 March 2026. doi:10.
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