Diagnostic, therapeutic, and prognostic characteristics of patients with acromegaly according to tumor size at diagnosis
Authors' conclusion
Adenomas < 20 mm showed lower morbidity and better therapeutic response in acromegaly, while those ≥ 20 mm had similar clinical, therapeutic, and prognostic behavior.
Study context
- Population
- Patients with acromegaly (growth hormone (GH)-secreting pituitary adenoma) followed at a tertiary center; 59 women, age at diagnosis 43 ± 13 years
- Participants
- 117 patients
- Exposure
- Adenoma size groups at diagnosis
- In = 11
- IIn = 54
- IIIn = 34
- IVn = 10
- Vn = 8
- Outcome
- Characteristics by adenoma size
Methodological detailsobservational, single-center
- Observational
- Single-center
Main finding
As reported in the abstract
- Prevalence of hypopituitarism, cavernous sinus invasion, GH levels and SRL use increased with adenoma size
- Age correlated negatively with tumor size
- Tumor diameter around 20 mm was the best predictor of hypopituitarism, invasiveness, need of adjuvant therapies and poorer disease control
Observational data: associations, not effects.
Original publication
Diagnostic, therapeutic, and prognostic characteristics of patients with acromegaly according to tumor size at diagnosis. Pituitary. Published 1 August 2024. doi:10.
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