The diverging role of O-GlcNAc transferase in corticotroph and somatotroph adenomas
Authors' conclusion
O-GlcNAcylation can be downregulated in non-cancerous tumors such as GH-secreting adenomas. Future studies are warranted to elucidate the role of OGT in the pathogenesis of PAs.
Study context
- Population
- Functioning PA and nonfunctioning PA (NFPA) from operated patients, plus postmortem normal and tumoral pituitary tissue
- Participants
- 60 PA specimens
- Outcome
- OGT expression in PA
Methodological detailsimmunohistochemistry, transcriptomic analyses
- Immunohistochemistry
- Transcriptomic analyses
Main finding
As reported in the abstract
- O-GlcNAc Transferase (OGT) strongly associated with hormone secretory capacity in functioning PA and with tumor growth in NFPA
- NFPA: OGT positively associated with tumor size, not with cavernous sinus invasion (Knosp grading)
- GH-secreting PA: OGT expression negatively correlated with circulating IGF-1
- Adrenocorticotropic hormone (ACTH)-secreting PA: OGT expression positively associated with circulating ACTH
- Secreting PA: OGT did not correlate with tumor size
- OGT higher in gonadotroph PA vs normal glands
Original publication
The diverging role of O-GlcNAc transferase in corticotroph and somatotroph adenomas. Pituitary. Published 27 July 2024. doi:10.
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