Neuroendocrine challenges and clinical outcomes in men with chronic traumatic brain injury: a cross-sectional study
Authors' conclusion
This study emphasizes the need to screen TBI patients for neuroendocrine dysfunction during the chronic phases and to establish screening criteria.
Study context
- Population
- Men aged 25–45 years with moderate to severe traumatic brain injury (TBI) within 6–24 months of injury; mean age 32.8 ± 5.7 years
- Participants
- 66 men
- Outcome
- Prevalence and types of endocrine dysfunction
Main finding
As reported in the abstract
Endocrine dysfunction
Hypopituitarism
56.1%
Observational data: associations, not effects.
Further findings
Hypogonadism by functional status (MBI)
P = 0.011
Factors associated with hypopituitarism (univariate logistic regression)
- Severity of injury, OR
- 2.6
- Glasgow Outcome Scale Extended (GOS-E), OR
- 3.1
- Significant (P < 0.10) on univariate analysis
Original publication
Neuroendocrine challenges and clinical outcomes in men with chronic traumatic brain injury: a cross-sectional study. Pituitary. Published 29 July 2024. doi:10.
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