Long-term pituitary function and functional and patient-reported outcomes in severe acquired brain injury
Authors' conclusion
Patients with severe acquired brain injury may develop long-term hypothalamus-pituitary insufficiency, with an equal occurrence in patients with TBI and NTBI. In both types of patients, mainly isolated deficiencies, most commonly affecting the gonadal axis, were seen. Insufficiencies were unrelated to functional outcomes and patient-reported outcomes, probably reflecting the complexity and heterogeneous manifestations in both patient groups.
Study context
- Population
- Patients admitted for inpatient neurorehabilitation after severe acquired brain injury; pituitary function assessed at a mean of 2.4 years after injury
- Participants
- 42 vs 18
- Exposure
- Severe traumatic brain injury (TBI) vs severe nontraumatic brain injury (NTBI)
- TBIn = 42
- NTBIn = 18reference
- Outcome
- Prevalence of hypopituitarism
- Follow-up
- Mean of 2.4 years after the injury
Main finding
As reported in the abstract
Hypopituitarism
P = 0.23
Observational data: associations, not effects.
Further findings
Number of axes affected among patients with hypopituitarism
- 1 axis (13 hypogonadotropic hypogonadism, 1 GH deficiency)
- 14/17 (82%)
- 2 axes (1 hypogonadotropic hypogonadism and GH deficiency; 2 hypogonadotropic hypogonadism and AVP deficiency)
- 3/17 (18%)
- Central hypoadrenalism or central hypothyroidism
- 0
Functional and patient-reported outcomes
- In both TBI and NTBI, pituitary status was unrelated to functioning and ability scores at 1 year and to patient-reported outcome scores at a mean of 2.4 years
Original publication
Long-term pituitary function and functional and patient-reported outcomes in severe acquired brain injury. Eur J Endocrinol. Published 29 April 2024. doi:10.
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