Long-term weight gain in children with craniopharyngioma
Authors' conclusion
Clinically significant weight gain occurred in nearly all children treated for craniopharyngioma, including those whose hypothalamus was spared by the tumour and intentionally by treatment. However, hypothalamus integrity was associated with less weight gain. Despite hypothalamus-sparing strategies, hypothalamic obesity remains a major concern, indicating a need for novel treatment approaches.
Study context
- Population
- Children managed for craniopharyngioma at a single centre between 1990 and 2019
- Participants
- 108 children
- Outcome
- Long-term weight changes in children treated for craniopharyngioma
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Overall mean BMI-SDS increase (P < .001)
2.11
Mean BMI-SDS increase without hypothalamic involvement by tumour (P < .001)
1.21
Mean BMI-SDS increase with intended hypothalamus-sparing surgery (P < .001)
1.95
Observational data: associations, not effects.
Secondary outcomes
Hypothalamic involvement and weight gain
- Absence of hypothalamic involvement by tumour significantly associated with less weight gain
- P = 0.046
- Absence of hypothalamic involvement by treatment significantly associated with less weight gain
- P < 0.01
Factors associated with BMI-SDS change >2 (adjusted)
- Female sex
- P = 0.023
- Tumour involving the hypothalamus
- P = 0.04
- Higher baseline body mass index (BMI)
- P < 0.001
- Multivariate analysis
Original publication
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