GH Stimulation testing is unnecessary in patients with hypothalamic–pituitary disease, preserved pituitary function, and IGF-I standard deviation scores (SDS) ≥ 0
Authors' conclusion
In adults with hypothalamic-pituitary disease but no additional hormonal deficiencies, IGF-I SDS values ≥ 0 identify a subgroup with a low, clinically acceptable probability of GHD, in whom stimulation testing may reasonably be avoided.
Study context
- Population
- Adults with hypothalamic-pituitary disease and preserved anterior pituitary function (no additional pituitary hormone deficiencies)
- Outcome
- Post-test probability of GHD by IGF-I SDS cut-off (≥ 0, ≥ 0.5, ≥ 1)
Methodological detailsBayesian approach, literature-derived data, proof-of-concept
- Bayesian approach
- Literature-derived data
- Proof-of-concept
Main finding
As reported in the abstract
Adult-onset growth hormone deficiency (GHD) probability
6.5% to 19.8%
Childhood-onset GHD probability
2.9% to 9.1%
Original publication
GH Stimulation testing is unnecessary in patients with hypothalamic–pituitary disease, preserved pituitary function, and IGF-I SDS ≥ 0. Pituitary. Published 23 July 2026. doi:10.
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