Management and follow-up strategies for patients with head and neck paraganglioma
Authors' conclusion
Patients without SDHx-related HNPGLs require long-term follow-up due to high prevalence of RD with imaging largely restricted to head-neck regions. As carotid-body HNPGLs have the highest metastatic risk among sporadic tumors, radical treatment with frequent follow-up is suggested until population-based data are available. Importantly, patients with SDHx-related HNPGLs might benefit from early radical treatment when tumors are still small to reduce metastatic risk.
Study context
- Population
- Patients with head-neck paragangliomas (HNPGLs), with and without SDHx pathogenic variants (PVs), enrolled in six referral centers
- Participants
- 214 patients6 referral centers
- Exposure
- SDHx-related vs non-SDHx-related HNPGLs
- Outcome
- Prevalence and predictors of recurrent (RD) and/or metastatic disease
Methodological detailsretrospective data, multicentre (six referral centers)
- Retrospective data
- Multicentre (six referral centers)
Main finding
As reported in the abstract
- Metastatic prevalence
- 9%-13%
Observational data: associations, not effects.
Further findings
Independent predictors of metastasis, SDHx-related HNPGLs
- Large tumor size (>2.3 cm), OR
- 50.0 (CI 2.6-977.6)
- Young age at initial diagnosis (<42years), OR
- 27.3 (CI 1.8-407.2)
- Presence of SDHB PV, OR
- 15.6 (CI 1.5-164.8)
Independent predictors of metastasis, without SDHx-related HNPGLs
- Carotid-body location (only independent predictor), OR
- 18.9 (CI 2.0-182.5)
Original publication
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