Anthropometric Measures Among Children and Teens With Classic 46,XX Congenital Adrenal Hyperplasia in Relation to Improvements in Diagnosis and Care
Authors' conclusion
There is substantial heterogeneity in growth trajectories of CAH patients. Although stunting may affect CAH patients, advances in diagnosis and care improved anthropometric outcomes in this population. Understanding the disease- and therapy-related mechanisms that explain the different growth patterns requires additional research.
Study context
- Population
- Patients <21 years of age with classic 46XX congenital adrenal hyperplasia (CAH) and matched referents, 3 large integrated health-systems
- Participants
- 76 vs 1,102
- Exposure
- Classic 46,XX CAH vs matched referents
- CAHn = 76
- Referentsn = 1,102reference
- Outcome
- Anthropometric measurements: age-specific percentiles for height, weight and BMI
Methodological detailsnested within 3 large integrated health-systems, matched referents
- Nested within 3 large integrated health-systems
- Matched referents
Main finding
As reported in the abstract
Differences ranged
10.7% to 28.4%
Observational data: associations, not effects.
Further findings
Latent class analysis of height: "gradual growth increase" pattern
Latent class analysis of height: "growth stunting" pattern
Height percentiles in CAH with vs without hormonal interventions (GH and/or puberty blockers)
- Height percentile measures did not differ
Original publication
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